KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL-Reference-Cited by-同舟云学术

KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL

Published:2014-10-23 Issue:17 Volume:124 Page:2744-2747
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Oevermann Lena¹,Michaelis Sebastian U.¹,Mezger Markus¹,Lang Peter¹,Toporski Jacek²,Bertaina Alice³,Zecca Marco⁴,Moretta Lorenzo⁵,Locatelli Franco³,Handgretinger Rupert¹

Affiliation:

1. Children’s Hospital, University of Tübingen, Germany;

2. Department of Pediatric Oncology, University Hospital Lund, Sweden;

3. Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesù, Rome, University of Pavia, Italy;

4. Pediatric Hematology/Oncology, Fondazione, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico, San Matteo, Pavia, Italy;

5. Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Giannina Gaslini, Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genova, Italy

Abstract

Key Points KIR haplotype B donors and high KIR B content score confer better protection against relapse after HLA-haploidentical transplantation in pediatric acute lymphoblastic leukemia. Haploidentical donor selection criteria for childhood acute lymphoblastic leukemia should include KIR haplotype and KIR B-content score.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/17/2744/1380729/2744.pdf

Reference17 articles.

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4. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.;Ruggeri;Science,2002

5. Determinants of antileukemia effects of allogeneic NK cells.;Leung;J Immunol,2004

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