KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia-Reference-Cited by-同舟云学术

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia

Published:2014-07-31 Issue:5 Volume:124 Page:803-811
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liu Dun¹,Zhang Xinhua²,Yu Lihua¹,Cai Ren³,Ma Xiaoxia¹,Zheng Chengguang⁴,Zhou Yuqiu⁵,Liu Qiji⁶,Wei Xiaofeng¹,Lin Li¹,Yan Tizhen³,Huang Jiwei¹,Mohandas Narla⁷,An Xiuli⁷,Xu Xiangmin¹

Affiliation:

1. Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China;

2. Department of Hematology, 303rd Hospital of the People's Liberation Army, Nanning, Guangxi, China;

3. Department of Birth Health and Heredity, Liuzhou Women and Children Care Hospital, Liuzhou, Guangxi, China;

4. Prenatal Diagnostic Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, Guangxi, China;

5. Department of Birth Health and Heredity, Zhuhai Women and Children Care Hospital, Zhuhai, Guangdong, China;

6. Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, School of Medicine, Shandong University, Jinan, Shandong, China; and

7. Red Cell Physiology Laboratory, New York Blood Center, New York, NY

Abstract

Key Points The prevalence of KLF1 mutations is significantly higher in a thalassemia endemic region of China than in a nonendemic region. KLF1 mutations ameliorate the clinical and hematologic features of β-thalassemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/5/803/541637/803.pdf

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