HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders-Reference-Cited by-同舟云学术

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders

Published:2014-07-31 Issue:5 Volume:124 Page:822-826
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bertaina Alice¹,Merli Pietro¹,Rutella Sergio¹²,Pagliara Daria¹,Bernardo Maria Ester¹,Masetti Riccardo³,Pende Daniela⁴,Falco Michela⁵,Handgretinger Rupert⁶,Moretta Francesca¹,Lucarelli Barbarella¹,Brescia Letizia P.¹,Li Pira Giuseppina¹,Testi Manuela⁷,Cancrini Caterina⁸,Kabbara Nabil⁹,Carsetti Rita¹,Finocchi Andrea⁸,Moretta Alessandro¹⁰,Moretta Lorenzo⁵,Locatelli Franco¹¹¹

Affiliation:

1. Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children’s Hospital, Rome, Italy;

2. Department of Medical Sciences, Catholic University Medical School, Rome, Italy;

3. Department of Pediatrics, Sant’Orsola Hospital, University of Bologna, Bologna, Italy;

4. Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy;

5. Istituto di Ricovero e Cura a Carattere Scientifico Giannina Gaslini, Genoa, Italy;

6. Children’s University Hospital, University of Tuebingen, Tuebingen, Germany;

7. Laboratory of Immunogenetics and Transplant Biology, Istituto Mediterraneo di Ematologia Foundation at Tor Vergata University Hospital, Rome, Italy;

8. University Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children’s Hospital, University of Rome Tor Vergata, Rome, Italy;

9. Pediatric Hematology Oncology Division, Rafic Hariri University Hospital, Beirut, Lebanon;

10. Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Università di Genova, Genoa, Italy; and

11. Department of Pediatrics, University of Pavia, Pavia, Italy

Abstract

Key Points Removal of αβ+ T and CD19+ B cells is an effective strategy for successful HLA-haploidentical hematopoietic stem cell transplantation. The high probability of disease-free survival renders this transplant option attractive for any child with a nonmalignant disorder.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/5/822/541634/822.pdf

Reference26 articles.

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4. Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference.;Locatelli;Clin Immunol,2009

5. Transplants across human leukocyte antigen barriers.;Martelli;Semin Hematol,2002

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