HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse-Reference-Cited by-同舟云学术

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

Published:2014-07-24 Issue:4 Volume:124 Page:638-644
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Martelli Massimo F.¹,Di Ianni Mauro¹²,Ruggeri Loredana¹,Falzetti Franca¹,Carotti Alessandra¹,Terenzi Adelmo¹,Pierini Antonio¹,Massei Maria Speranza¹,Amico Lucia¹,Urbani Elena¹,Del Papa Beatrice¹,Zei Tiziana¹,Iacucci Ostini Roberta¹,Cecchini Debora¹,Tognellini Rita³,Reisner Yair⁴,Aversa Franco⁵,Falini Brunangelo¹,Velardi Andrea¹

Affiliation:

1. Division of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy;

2. Hematology Section, Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy;

3. Blood Bank, Ospedale Santa Maria della Misericordia, Perugia, Italy;

4. Weizmann Institute of Science, Immunology Department, Rehovot, Israel; and

5. Hematology and Bone Marrow Transplant Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy

Abstract

Key Points Haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents high-risk acute leukemia relapse. The GVL effect is separated from GVHD even across major HLA barriers.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/4/638/1382428/638.pdf

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5. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts.;Weiden;N Engl J Med,1979

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