Identification of CD34+ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Identification of CD34+ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

Published:2015-02-05 Issue:6 Volume:125 Page:967-980
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Aoki Yuki¹²,Watanabe Takashi³,Saito Yoriko¹,Kuroki Yoko³,Hijikata Atsushi³,Takagi Masatoshi²,Tomizawa Daisuke⁴,Eguchi Mariko⁵,Eguchi-Ishimae Minenori⁵,Kaneko Akiko¹,Ono Rintaro¹,Sato Kaori¹,Suzuki Nahoko¹,Fujiki Saera¹,Koh Katsuyoshi⁶,Ishii Eiichi⁵,Shultz Leonard D.⁷,Ohara Osamu³⁸,Mizutani Shuki²,Ishikawa Fumihiko¹

Affiliation:

1. Laboratory for Human Disease Models RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;

2. Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan;

3. Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;

4. Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan;

5. Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan;

6. Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan;

7. The Jackson Laboratory, Bar Harbor, ME; and

8. Kazusa DNA Research Institute, Kisarazu, Chiba, Japan

Abstract

Key Points Using an in vivo model for primary MLL-rearranged infant ALL, we identified phenotypically and functionally distinct LICs and HSCs. In MLL ALL patient samples, molecules differentially expressed between LICs and HSCs including CD9, CD32, and CD24 were identified.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/6/967/1387613/967.pdf

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