PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events-Reference-Cited by-同舟云学术

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

Published:2014-07-24 Issue:4 Volume:124 Page:567-578
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mendes Rui D.¹,Sarmento Leonor M.²,Canté-Barrett Kirsten¹,Zuurbier Linda¹,Buijs-Gladdines Jessica G. C. A. M.¹,Póvoa Vanda²,Smits Willem K.¹,Abecasis Miguel³,Yunes J. Andres⁴,Sonneveld Edwin⁵,Horstmann Martin A.⁶⁷,Pieters Rob¹⁸,Barata João T.²,Meijerink Jules P. P.¹

Affiliation:

1. Department of Pediatric Oncology/Hematology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands;

2. Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal;

3. Cardiologia Pediatrica Medico Cirúrgica, Hospital Sta. Cruz, Lisboa, Portugal;

4. Centro Infantil Boldrini, Campinas, São Paulo, Brazil;

5. Dutch Childhood Oncology Group, The Hague, The Netherlands;

6. German Cooperative Study Group for Childhood Acute Lymphoblastic Leukemia, Hamburg, Germany;

7. Research Institute Children's Cancer Center Hamburg, Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; and

8. Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands

Abstract

Key Points Microdeletions represent an additional inactivation mechanism for PTEN in human T-cell acute lymphoblastic leukemia. PTEN microdeletions are RAG-mediated aberrations.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/4/567/1382329/567.pdf

Reference65 articles.

1. Treatment of acute lymphoblastic leukemia.;Pui;N Engl J Med,2006

2. Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia.;Meijerink;Best Pract Res Clin Haematol,2010

3. Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL.;Dik;Blood,2007

4. Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL.;Le Noir;Blood,2012

5. V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.;Marculescu;J Exp Med,2002

Cited by 73 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia;ELIFE;2024

2. RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia;eLife;2024-07-26

3. Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia;2024-06-20

4. Acute lymphoblastic leukaemia;Nature Reviews Disease Primers;2024-06-13

5. RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia;2024-05-09