Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice-Reference-Cited by-同舟云学术

Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice

Published:2014-10-23 Issue:17 Volume:124 Page:2625-2634
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ortiz-Muñoz Guadalupe¹,Mallavia Beñat¹,Bins Adriaan²,Headley Mark³,Krummel Matthew F.³,Looney Mark R.¹⁴

Affiliation:

1. Department of Medicine, University of California, San Francisco, San Francisco, CA;

2. Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands;

3. Department of Pathology and

4. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA

Abstract

Key Points Neutrophil-platelet aggregates are dynamically formed in the lung in response to injury and are regulated by aspirin-triggered lipoxin. The therapeutic effect of aspirin in acute lung injury is in large part mediated by the production of pro-resolving lipid mediators.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/17/2625/1380567/2625.pdf

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