The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth-Reference-Cited by-同舟云学术

The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth

Published:2006-03-15 Issue:6 Volume:107 Page:2330-2338
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kertesz Nathalie¹,Krasnoperov Valery¹,Reddy Ramachandra¹,Leshanski Lucy¹,Kumar S. Ram¹,Zozulya Sergey¹,Gill Parkash S.¹

Affiliation:

1. From Vasgene Therapeutics, Inc, and the Departments of Pathology, Surgery, and Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Abstract

AbstractThe receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis. The soluble monomeric derivative of the extracellular domain of EphB4 (sEphB4) was designed as an antagonist of EphB4/EphrinB2 signaling. sEphB4 blocks activation of EphB4 and EphrinB2; suppresses endothelial cell migration, adhesion, and tube formation in vitro; and inhibits the angiogenic effects of various growth factors (VEGF and bFGF) in vivo. sEphB4 also inhibits tumor growth in murine tumor xenograft models. sEphB4 is thus a therapeutic candidate for vascular proliferative diseases and cancer.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/107/6/2330/1286736/zh800606002330.pdf

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