Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity-Reference-Cited by-同舟云学术

Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity

Published:2014-01-30 Issue:5 Volume:123 Page:669-677
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vaughan Andrew T.¹,Iriyama Chisako¹²,Beers Stephen A.¹,Chan Claude H. T.¹,Lim Sean H.¹,Williams Emily L.¹,Shah Vallari¹,Roghanian Ali¹,Frendéus Bjorn³,Glennie Martin J.¹,Cragg Mark S.¹

Affiliation:

1. Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton, Faculty of Medicine, General Hospital, Southampton, United Kingdom;

2. Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan; and

3. Preclinical Research, BioInvent International AB, Lund, Sweden

Abstract

Key Points FcγRIIb-dependent internalization of therapeutic mAbs is dependent on antibody specificity. FcγRIIb can be activated in both cis and trans configurations.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/5/669/1379169/669.pdf

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