AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia-Reference-Cited by-同舟云学术

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

Published:2014-02-06 Issue:6 Volume:123 Page:905-913
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Keeton Erika K.¹,McEachern Kristen¹,Dillman Keith S.¹,Palakurthi Sangeetha¹,Cao Yichen¹,Grondine Michael R.¹,Kaur Surinder²³,Wang Suping¹,Chen Yuching¹,Wu Allan¹,Shen Minhui¹,Gibbons Francis D.¹,Lamb Michelle L.¹,Zheng Xiaolan¹,Stone Richard M.⁴,DeAngelo Daniel J.⁴,Platanias Leonidas C.²³,Dakin Les A.¹,Chen Huawei¹,Lyne Paul D.¹,Huszar Dennis¹

Affiliation:

1. Oncology iMed, AstraZeneca, Waltham, MA;

2. Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, IL;

3. Department of Medicine, Jesse Brown Veterans Administration Medical Center, Chicago, IL; and

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Abstract

Key Points AZD1208 is a selective pan-Pim kinase inhibitor with efficacy in AML cells, xenografts, and Flt3-internal tandem duplication or Flt3 wild-type patient samples. AML cell growth inhibition is associated with suppression of p70S6K, 4EBP1 phosphorylation, and messenger RNA translation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/6/905/1379188/905.pdf

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