The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects-Reference-Cited by-同舟云学术

The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects

Published:2014-03-20 Issue:12 Volume:123 Page:1905-1916
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Colucci Giuseppe¹,Stutz Monika¹,Rochat Sophie¹,Conte Tiziana¹,Pavicic Marko¹,Reusser Marianne¹,Giabbani Evelyne¹,Huynh Anh¹,Thürlemann Charles¹,Keller Peter¹,Alberio Lorenzo¹

Affiliation:

1. Department of Haematology and Central Haematology Laboratory, Inselspital, Bern University Hospital and University of Bern, Switzerland

Abstract

Key PointsDDAVP is the drug of choice for mild hemophilia A and von Willebrand disease and (by unclear mechanisms) for platelet function disorders. In vivo DDAVP selectively and markedly enhances the ability to form procoagulant platelets by enhancing intracellular Na+ and Ca2+ fluxes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/12/1905/1374680/1905.pdf

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