Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model-Reference-Cited by-同舟云学术

Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model

Published:2013-12-05 Issue:24 Volume:122 Page:3960-3963
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lascano Valeria¹,Guadagnoli Marco¹,Schot Jan G.²,Luijks Dieuwertje M.²,Guikema Jeroen E. J.³,Cameron Katherine¹,Hahne Michael⁴,Pals Steven³⁵,Slinger Erik²,Kipps Thomas J.⁶,van Oers Marinus H. J.²⁵,Eldering Eric⁵⁷,Medema Jan Paul¹,Kater Arnon P.²⁵

Affiliation:

1. Laboratory of Experimental Oncology and Radiobiology,

2. Department of Hematology, and

3. Department of Pathology, Academic Medical Center (AMC), Amsterdam, The Netherlands;

4. Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique, Montpellier, France;

5. LYMMCARE (Lymphoma and Myeloma Center Amsterdam), AMC, Amsterdam, The Netherlands;

6. Moores Cancer Center, University of California San Diego, La Jolla, CA; and

7. Laboratory of Experimental Immunology, AMC, Amsterdam, The Netherlands

Abstract

Key Points APRIL significantly accelerates CLL onset in TCL1-Tg mice. APRIL-mediated prosurvival effects in leukemic cells depend on TACI and not BCMA ligation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/24/3960/1370510/3960.pdf

Reference13 articles.

1. The microenvironment in mature B-cell malignancies: a target for new treatment strategies.;Burger;Blood,2009

2. Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.;Smit;Blood,2007

3. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia.;Herishanu;Blood,2011

4. BAFF, APRIL and their receptors: structure, function and signaling.;Bossen;Semin Immunol,2006

5. Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.;Kern;Blood,2004

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