Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis

Author:

Monnereau Alain123,Glaser Sally L.34,Schupp Clayton W.3,Ekström Smedby Karin5,de Sanjosé Silvia67,Kane Eleanor8,Melbye Mads9,Forétova Lenka10,Maynadié Marc11,Staines Anthony12,Becker Nikolaus13,Nieters Alexandra14,Brennan Paul15,Boffetta Paolo16,Cocco Pierluigi17,Glimelius Ingrid5,Clavel Jacqueline1,Hjalgrim Henrik9,Chang Ellen T.3418

Affiliation:

1. Environmental Epidemiology of Cancer Group, Centre for Research in Epidemiology and Population Health, Institut National de la Santé et de la Recherche Médicale U1018, Villejuif, France;

2. Registry of Hematological Malignancies in Gironde, Bergonié Institute, Bordeaux, France;

3. Cancer Prevention Institute of California, Fremont, CA;

4. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA;

5. Unit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden;

6. Unit of Infections and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Barcelona, Spain;

7. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona, Spain;

8. Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, United Kingdom;

9. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark;

10. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic;

11. Registre des Hémopathies Malignes de Côte d’Or, Université de Bourgogne and University Hospital, Dijon, France;

12. School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland;

13. Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany;

14. Centre of Chronic Immunodeficiency, Molecular Epidemiology, Universitätsklinikum Freiburg, Freiburg, Germany;

15. Genetics Section, International Agency for Research on Cancer, Lyon, France;

16. The Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, NY; and International Prevention Research Institute, Lyon, France;

17. Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Asse Didattico E, Monserrato, Italy; and

18. Health Sciences Practice, Exponent, Inc., Menlo Park, CA

Abstract

Key Points Our pooled analysis found an inverse association between several measures of UVR exposure and Hodgkin lymphoma. Significant UVR-related inverse associations of EBV-positive HL with a dose-response relationship support etiologic heterogeneity in HL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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