Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme

Author:

Garcia-Santos Daniel1,Schranzhofer Matthias1,Horvathova Monika2,Jaberi Mehrad Mojtahed1,Bogo Chies Jose Artur3,Sheftel Alex D.4,Ponka Prem1

Affiliation:

1. Lady Davis Institute for Medical Research, Jewish General Hospital, and the Department of Physiology, McGill University, Montréal, QC, Canada;

2. Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;

3. Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; and

4. High Impact Editing, Ottawa, ON, Canada

Abstract

Key Points Heme oxygenase-1 levels increase during erythroid differentiation. Heme oxygenase-1 actively participates in maintaining appropriate hemoglobinization rates.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference50 articles.

1. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.;Ponka;Blood,1997

2. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.;Balla;Proc Natl Acad Sci USA,1993

3. Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide?;Sassa;Antioxid Redox Signal,2004

4. The heme oxygenase system: a regulator of second messenger gases.;Maines;Annu Rev Pharmacol Toxicol,1997

5. The heme oxygenase system: update 2005.;Maines;Antioxid Redox Signal,2005

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