The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1-Reference-Cited by-同舟云学术

The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1

Published:2013-12-19 Issue:26 Volume:122 Page:4237-4245
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cader Fathima Zumla¹²,Vockerodt Martina¹,Bose Shikha¹,Nagy Eszter¹,Brundler Marie-Anne²,Kearns Pamela¹²,Murray Paul G.¹

Affiliation:

1. School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; and

2. Birmingham Children’s Hospital, Birmingham, United Kingdom

Abstract

Key Points Expression of the EBV oncogene LMP1 in primary human germinal center B cells, upregulates DDR1, a receptor tyrosine kinase activated by collagen Primary HRS cells overexpress DDR1, and its activation significantly increases lymphoma cell survival in vitro

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/26/4237/1372619/4237.pdf

Reference52 articles.

1. The biology of Hodgkin’s lymphoma.;Küppers;Nat Rev Cancer,2009

2. The classical Hodgkin’s lymphoma microenvironment and its role in promoting tumour growth and immune escape.;Aldinucci;J Pathol,2010

3. Collagen density promotes mammary tumor initiation and progression.;Provenzano;BMC Med,2008

4. Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis.;Valencia;Clin Cancer Res,2012

5. Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.;Shields;Biochem J,2012

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