Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes-Reference-Cited by-同舟云学术

Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes

Published:2013-08-22 Issue:8 Volume:122 Page:1399-1410
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Abate-Daga Daniel¹,Hanada Ken-ichi¹,Davis Jeremy L.¹,Yang James C.¹,Rosenberg Steven A.¹,Morgan Richard A.¹

Affiliation:

1. Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD

Abstract

Key Points Gene expression in TCR-engineered cells resembles that of virus-reactive cells more than native tumor antigen-reactive cells. Persisting TCR gene–engineered T cells are sensitive to PD-L1–PD-1 interaction but CD160-associated impairment is ligand-independent.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/8/1399/1374002/1399.pdf

Reference49 articles.

1. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.;Rosenberg;Clin Cancer Res,2011

2. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.;Kochenderfer;Blood,2012

3. Cancer regression in patients after transfer of genetically engineered lymphocytes.;Morgan;Science,2006

4. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.;Johnson;Blood,2009

5. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1.;Robbins;J Clin Oncol,2011

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