VEGFD regulates blood vascular development by modulating SOX18 activity-Reference-Cited by-同舟云学术

VEGFD regulates blood vascular development by modulating SOX18 activity

Published:2014-02-13 Issue:7 Volume:123 Page:1102-1112
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Duong Tam¹,Koltowska Katarzyna¹,Pichol-Thievend Cathy¹,Le Guen Ludovic¹,Fontaine Frank¹,Smith Kelly A.¹,Truong Vy¹,Skoczylas Renae¹,Stacker Steven A.²³,Achen Marc G.²³,Koopman Peter¹,Hogan Benjamin M.¹,Francois Mathias¹

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia;

2. Tumour Angiogenesis Program, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, VIC, Australia; and

3. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia

Abstract

Key Points Haploinsufficiency of Sox18 reveals an important role for VEGFD in regulating blood vascular development in vivo in vertebrates. VEGFD acts through mitogen-activated protein kinase kinase–extracellular signal-regulated kinase to modulate the activity and nuclear concentration of endothelial-specific transcription factor SOX18.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/7/1102/538084/1102.pdf

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