The effect of rituximab on vaccine responses in patients with immune thrombocytopenia

Author:

Nazi Ishac1,Kelton John G.1,Larché Mark1,Snider Denis P.2,Heddle Nancy M.1,Crowther Mark A.1,Cook Richard J.3,Tinmouth Alan T.456,Mangel Joy7,Arnold Donald M.18

Affiliation:

1. Department of Medicine and

2. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada;

3. Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada;

4. Department of Medicine, Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada;

5. University of Ottawa Centre for Transfusion, Ottawa Hospital Research Institute, Ottawa, ON, Canada;

6. Canadian Blood Services, Ottawa, ON, Canada;

7. Department of Medicine, Schulich School of Medicine, University of Western Ontario, London, ON, Canada; and

8. Canadian Blood Services, Hamilton, ON, Canada

Abstract

Key PointsAfter treatment with rituximab, immunological responses to both polysaccharide and conjugated vaccines are impaired in patients with ITP. Splenectomized patients who received rituximab may be at increased risk of infection because of compromised immune responses to vaccines.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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