Mast cell activation contributes to sickle cell pathobiology and pain in mice-Reference-Cited by-同舟云学术

Mast cell activation contributes to sickle cell pathobiology and pain in mice

Published:2013-09-12 Issue:11 Volume:122 Page:1853-1862
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vincent Lucile¹,Vang Derek¹,Nguyen Julia¹,Gupta Mihir²,Luk Kathryn¹,Ericson Marna E.³,Simone Donald A.⁴,Gupta Kalpna¹

Affiliation:

1. Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN;

2. Stanford University School of Medicine, Stanford, CA; and

3. Department of Dermatology and

4. Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN

Abstract

Key Points Inhibition of mast cells with cromolyn or imatinib results in reduced systemic inflammation and neurogenic inflammation in sickle mice. Pharmacological inhibition or genetic depletion of mast cells in sickle mice ameliorates chronic and hypoxia/reoxygenation-induced pain.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/11/1853/1331095/1853.pdf

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5. Pain management in sickle cell disease: palliative care begins at birth?;Benjamin;Hematology (Am Soc Hematol Educ Program),2008

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