Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses-Reference-Cited by-同舟云学术

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

Published:2013-08-08 Issue:6 Volume:122 Page:932-942
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nizzoli Giulia¹,Krietsch Jana²³,Weick Anja²³,Steinfelder Svenja²³,Facciotti Federica¹,Gruarin Paola¹,Bianco Annalisa¹,Steckel Bodo²³,Moro Monica¹,Crosti Mariacristina¹,Romagnani Chiara²³,Stölzel Katharina³,Torretta Sara⁴,Pignataro Lorenzo⁴,Scheibenbogen Carmen³,Neddermann Petra¹,De Francesco Raffaele¹,Abrignani Sergio¹,Geginat Jens¹

Affiliation:

1. INGM (National Institute of Molecular Genetics), Milan, Italy;

2. DRFZ (German Rheumatology Research Institute), Berlin, Germany;

3. Charité Universitätsmedizin, Berlin, Germany; and

4. Department of Clinical Sciences and Community Health, University of Milan, Unità Operativa Otorinolaringoiatria, “Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico,” Milan, Italy

Abstract

Key Points CD1c+ DC but not BDCA-3+ DC or other antigen-presenting cells secrete high amounts of bioactive IL-12. CD1c+ DC efficiently cross-present antigens, prime CD8+ T cells, and induce the highest levels of cytotoxic molecules.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/6/932/1375770/932.pdf

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4. Help for cytotoxic-T-cell responses is mediated by CD40 signalling.;Bennett;Nature,1998

5. Development of antigen cross-presentation capacity in dendritic cells.;Dresch;Trends Immunol,2012

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