BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein-Reference-Cited by-同舟云学术

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Published:2014-11-20 Issue:22 Volume:124 Page:3260-3273
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Agarwal Anupriya¹^ORCID,Mackenzie Ryan J.¹,Besson Arnaud²,Jeng Sophia³,Carey Alyssa¹,LaTocha Dorian H.¹,Fleischman Angela G.¹,Duquesnes Nicolas²,Eide Christopher A.¹⁴,Vasudevan Kavin B.¹,Loriaux Marc M.¹⁵,Firpo Eduardo⁶,Cortes Jorge E.⁷,McWeeney Shannon³,O’Hare Thomas⁸⁹,Roberts James M.⁶,Druker Brian J.¹⁴,Deininger Michael W.⁸⁹

Affiliation:

1. Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR;

2. Cancer Research Center of Toulouse, INSERM Unité Mixte de Recherche 1037, Université de Toulouse, Toulouse, France;

3. Division of Bioinformatics & Computational Biology, Knight Cancer Institute,

4. Howard Hughes Medical Institute, and

5. Department of Pathology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR;

6. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA;

7. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX; and

8. Division of Hematology and Hematologic Malignancies and

9. Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT

Abstract

Key Points Coordinated BCR-ABL1 kinase-dependent and -independent mechanisms convert p27 from a nuclear tumor suppressor to a cytoplasmic oncogene. Oncogenic functions of p27 that persist despite effective BCR-ABL1 inhibition may contribute to resistance to tyrosine kinase inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/22/3260/1464913/3260.pdf

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