Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Author:

Matafonov Anton12,Leung Philberta Y.34,Gailani Adam E.1,Grach Stephanie L.1,Puy Cristina3,Cheng Qiufang1,Sun Mao-fu1,McCarty Owen J. T.3,Tucker Erik I.34,Kataoka Hiroaki5,Renné Thomas67,Morrissey James H.8,Gruber Andras34,Gailani David1

Affiliation:

1. Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN;

2. Department of Bioengineering and Organic Chemistry, Tomsk Polytechnic University, Tomsk, Russia;

3. Departments of Biomedical Engineering and Medicine, Oregon Health and Science University, Portland, OR;

4. Aronora, Inc., Portland, OR;

5. Department of Pathology, University of Miyazaki, Miyazaki, Japan;

6. Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden;

7. Institute of Clinical Chemistry, University Hospital Hamburg-Eppendorf, Hamburg, Germany; and

8. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL

Abstract

Key Points Factor XII can contribute to thrombus formation in human and nonhuman primate blood. An antibody that blocks factor XII activation (15H8) produces an antithrombotic effect in a primate thrombosis model.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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