Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia

Published:2017-12-21 Issue:25 Volume:130 Page:2750-2761
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Serafin Valentina¹,Capuzzo Giorgia¹,Milani Gloria¹,Minuzzo Sonia Anna²,Pinazza Marica³,Bortolozzi Roberta¹,Bresolin Silvia¹,Porcù Elena¹,Frasson Chiara¹²³⁴,Indraccolo Stefano³,Basso Giuseppe¹,Accordi Benedetta¹

Affiliation:

1. Department of Woman’s and Child’s Health and

2. Immunology and Oncology Section, Department of Surgery, Oncology, and Gastroenterology, University of Padova, Padova, Italy;

3. Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IRCCS, Padova, Italy; and

4. Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy

Abstract

Key Points Resistance to glucocorticoid treatment in pediatric T-ALL can be reversed by LCK inhibitors in vitro and in vivo. IL-4 overexpression contributes to LCK-induced glucocorticoid resistance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/25/2750/1404222/blood784603.pdf

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