Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation

Author:

Pang Aiming12,Cui Yujie13,Chen Yunfeng45,Cheng Ni1,Delaney M. Keegan16,Gu Minyi6,Stojanovic-Terpo Aleksandra1,Zhu Cheng457,Du Xiaoping1

Affiliation:

1. Department of Pharmacology, University of Illinois at Chicago, Chicago, IL;

2. Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood Diseases Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, China;

3. School of Medical Laboratory, Tianjin Medical University, Tianjin, China;

4. Woodruff School of Mechanical Engineering and

5. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA;

6. Dupage Medical Technology, Inc., Willowbrook, IL; and

7. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA

Abstract

Key Points Shear-induced, Gα13-mediated integrin outside-in signaling facilitates platelet PS exposure, MV release, and coagulation. An inhibitor of outside-in signaling inhibits not only occlusive platelet thrombus formation but also intravascular coagulation in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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