Phase 1 clinical trial evaluating abatacept in patients with steroid-refractory chronic graft-versus-host disease-Reference-Cited by-同舟云学术

Phase 1 clinical trial evaluating abatacept in patients with steroid-refractory chronic graft-versus-host disease

Published:2018-06-21 Issue:25 Volume:131 Page:2836-2845
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nahas Myrna R.¹^ORCID,Soiffer Robert J.²,Kim Haesook T.²,Alyea Edwin P.²,Arnason Jon¹,Joyce Robin¹,Antin Joseph H.²,Ho Vincent T.²,Stroopinsky Dina¹,Li Shuli²,Levine James D.¹,McMasters Malgorzata¹,Jain Salvia¹,Hamdan Ayad¹,Tzachanis Dimitrios³,Bryant Mary Paty¹,Logan Emma K.¹,Bazemore Josie¹,Stewart Jeremy²,Joyce Amy²,Stephenson Susan²,Washington Abigail¹,Cole Leandra¹,Pyzer Athalia¹,Leaf Rebecca Karp¹,Avigan David E.¹,Rosenblatt Jacalyn¹

Affiliation:

1. Section of Hematological Malignancies and Bone Marrow Transplantation, Beth Israel Deaconess Medical Center, and

2. Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and

3. Blood and Marrow Transplant Program, University of California, San Diego, La Jolla, CA

Abstract

Key Points Costimulatory blockade using abatacept represents a novel therapeutic approach for the treatment of cGVHD. Abatacept resulted in a clinical response in 44% of patients with both decreased prednisone use and T-cell PD-1 expression in responders.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/25/2836/1465929/blood780239.pdf

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