Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome-Reference-Cited by-同舟云学术

Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome

Published:2017-08-31 Issue:9 Volume:130 Page:1144-1155
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nowak Roberta B.¹,Papoin Julien²,Gokhin David S.¹,Casu Carla³,Rivella Stefano³^ORCID,Lipton Jeffrey M.²⁴⁵,Blanc Lionel²⁴⁵^ORCID,Fowler Velia M.¹^ORCID

Affiliation:

1. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA;

2. Center for Autoimmune and Musculoskeletal Disorders, Feinstein Institute for Medical Research, Manhasset, NY;

3. Division of Hematology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA; and

4. Department of Molecular Medicine and

5. Department of Pediatrics, Hofstra-Northwell School of Medicine, Hempstead, NY

Abstract

Key Points Morphological dissection of the progression of nuclear expulsion reveals complex F-actin rearrangements in primary erythroblasts. Enucleation depends upon a novel, conserved, F-actin/myosin IIB/Tmod1 structure (the “enucleosome”) at the rear of the translocating nucleus.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/9/1144/1405359/blood787051.pdf

Reference47 articles.

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4. Erythroblast enucleation;Keerthivasan,2011

5. Ontogeny of erythropoiesis;Palis;Curr Opin Hematol,2008

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