Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis

Author:

Zhang Ying123,Xue Yuanyuan24,Cao Chunwei13,Huang Jiaojiao13,Hong Qianlong13,Hai Tang13,Jia Qitao13,Wang Xianlong13,Qin Guosong13,Yao Jing13,Wang Xiao13,Zheng Qiantao13,Zhang Rui13,Li Yongshun13,Luo Ailing13,Zhang Nan13,Shi Guizhi5,Wang Yanfang6,Ying Hao7,Liu Zhonghua38,Wang Hongmei123,Meng Anming39,Zhou Qi123,Wei Hong310,Liu Feng24,Zhao Jianguo123

Affiliation:

1. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;

2. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China;

3. Chinese Swine Mutagenesis Consortium;

4. State Key Laboratory of Membrane Biology, Institute of Zoology, and

5. Laboratory Animal Center, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;

6. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China;

7. Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China;

8. College of Life Science, Northeast Agricultural University of China, Harbin, China;

9. School of Life Sciences, Tsinghua University, Beijing, China; and

10. Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China

Abstract

Key Points A severe hypothyroid pig model created by ENU mutagenesis manifests the clinical features of human patients. KLF9 acts as a critical mediator between the thyroid axis and hematopoiesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference52 articles.

1. Hypothyroidism in the newborn period;Wassner;Curr Opin Endocrinol Diabetes Obes,2013

2. Regenerative therapy for hypothyroidism: mechanisms and possibilities;Hollenberg;Mol Cell Endocrinol,2017

3. Anemia in infants with congenital hypothyroidism diagnosed by neonatal screening;Franzese;J Endocrinol Invest,1996

4. The association between hypothyroidism and anemia: a clinical study;Kazemi-Jahromi;Int J Hematol Oncol Stem Cell Res,2010

5. Congenital hypothyroidism presenting with severe neonatal anaemia;Das;Curr Pediatr Res,2015

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