1. Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol;
2. Centre for Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham;
3. Department of Cardiovascular Science, University of Sheffield, Sheffield;
4. Department of Haematology, The Birmingham Children's Hospital National Health Service Trust, Birmingham;
5. Department of Biosciences, College of Life Sciences, Birmingham University, Birmingham; and
6. Department of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom