Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease-Reference-Cited by-同舟云学术

Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease

Published:2015-10-08 Issue:15 Volume:126 Page:1831-1834
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mankelow Tosti J.¹,Griffiths Rebecca E.¹^ORCID,Trompeter Sara²^ORCID,Flatt Joanna F.¹^ORCID,Cogan Nicola M.¹,Massey Edwin J.¹,Anstee David J.¹

Affiliation:

1. Bristol Institute for Transfusion Sciences, National Health Service Blood and Transplant, Filton, Bristol, United Kingdom, and

2. Joint Red Cell Unit, University College London National Health Service Foundation Trust, Haematology Department, London, United Kingdom

Abstract

Key Points Reticulocyte maturation involves the release of intact, inside-out autophagic vesicles with PS exposed on their surface. Elevated levels of autophagic vesicles on circulating reticulocytes cause PS exposure in patients with SCD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/15/1831/1389302/1831.pdf

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