Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation-Reference-Cited by-同舟云学术

Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation

Published:2016-02-04 Issue:5 Volume:127 Page:626-636
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Estevez Brian¹,Kim Kyungho¹,Delaney M. Keegan¹,Stojanovic-Terpo Aleksandra¹,Shen Bo¹,Ruan Changgeng²,Cho Jaehyung¹,Ruggeri Zaverio M.³,Du Xiaoping¹

Affiliation:

1. Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL;

2. Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China; and

3. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

Abstract

Key Points GPIb-IX signaling cooperates with PAR signaling to promote platelet response to low concentrations of thrombin, which are important in vivo. Thrombin induces a GPIb-IX–specific signaling pathway that requires the cytoplasmic domain of GPIbα, 14-3-3 protein, Rac1, and LIMK1.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/5/626/1395194/626.pdf

Reference57 articles.

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4. Role of thrombin signalling in platelets in haemostasis and thrombosis.;Sambrano;Nature,2001

5. Protease-activated receptors in hemostasis, thrombosis and vascular biology.;Coughlin;J Thromb Haemost,2005

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