Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3-Reference-Cited by-同舟云学术

Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3

Published:2015-10-29 Issue:18 Volume:126 Page:2138-2145
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhu Jianghai¹²,Zhu Jieqing¹²,Bougie Daniel W.³,Aster Richard H.³⁴,Springer Timothy A.¹²

Affiliation:

1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA;

2. Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, MA;

3. Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI; and

4. Department of Medicine, Medical College of Wisconsin, Milwaukee WI

Abstract

Key Points Quinine binds to quinine-dependent antibodies first and causes CDR loop reconfiguration. A hybrid paratope consisting of quinine and reconfigured CDR recognizes its target epitope.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/18/2138/1389570/2138.pdf

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