Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib

Author:

Sun Clare1ORCID,Tian Xin2,Lee Yuh Shan1,Gunti Sreenivasulu3,Lipsky Andrew1,Herman Sarah E. M.1,Salem Dalia4,Stetler-Stevenson Maryalice4,Yuan Constance4,Kardava Lela5,Moir Susan5,Maric Irina6,Valdez Janet1,Soto Susan1,Marti Gerald E.7,Farooqui Mohammed Z.1,Notkins Abner L.3,Wiestner Adrian1,Aue Georg1

Affiliation:

1. Hematology Branch and

2. Office of Biostatistics Research, National Heart, Lung, and Blood Institute,

3. Experimental Medicine Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research,

4. Laboratory of Pathology, National Cancer Institute,

5. Laboratories of Immunoregulation, National Institute of Allergy and Infectious Diseases, and

6. Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD; and

7. Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD

Abstract

Key Points Ibrutinib allows for partial reconstitution of normal B cells and humoral immunity in patients with chronic lymphocytic leukemia. Infection rate decreased with time on ibrutinib and was inversely correlated with improvements in serum IgA.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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