Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia

Author:

Ciurea Stefan O.1,Zhang Mei-Jie23,Bacigalupo Andrea A.4,Bashey Asad5,Appelbaum Frederick R.6,Aljitawi Omar S.7,Armand Philippe8,Antin Joseph H.8,Chen Junfang2,Devine Steven M.9,Fowler Daniel H.10,Luznik Leo11,Nakamura Ryotaro12,O’Donnell Paul V.6,Perales Miguel-Angel13,Pingali Sai Ravi1,Porter David L.14,Riches Marcie R.15,Ringdén Olle T. H.16,Rocha Vanderson17,Vij Ravi18,Weisdorf Daniel J.19,Champlin Richard E.1,Horowitz Mary M.2,Fuchs Ephraim J.11,Eapen Mary2

Affiliation:

1. Department of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX;

2. Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

3. Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI;

4. Department of Hematology, IRCCS Azienda Ospedaliera Universitaria (AOU) San Martino—IST, Genoa, Italy;

5. Department of Medicine, Northside Hospital, Atlanta, GA;

6. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

7. Department of Medicine, University of Kansas Medical Center, Kansas City, KS;

8. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

9. Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Arthur C. James Cancer Hospital, Columbus, OH;

10. Experimental Transplantation and Immunobiology, Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD;

11. Department of Medicine – Hematology, Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD;

12. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA;

13. Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY;

14. Hematology-Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA;

15. Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

16. Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden;

17. Churchill Hospital, Oxford, United Kingdom;

18. Division of Hematology and Oncology, Washington University School of Medicine, Saint Louis, MO; and

19. Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN

Abstract

Key Points Lower GVHD after haploidentical transplant with posttransplant cyclophosphamide compared with HLA-matched unrelated donor transplant. Comparable overall survival after haploidentical compared with matched unrelated donor transplant for AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference36 articles.

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