NBS1 is required for macrophage homeostasis and functional activity in mice-Reference-Cited by-同舟云学术

NBS1 is required for macrophage homeostasis and functional activity in mice

Published:2015-11-26 Issue:22 Volume:126 Page:2502-2510
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pereira-Lopes Selma¹,Tur Juan¹,Calatayud-Subias Juan A.¹,Lloberas Jorge¹,Stracker Travis H.²,Celada Antonio¹

Affiliation:

1. Biology of Macrophage, Department of Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain; and

2. Institute for Research in Biomedicine, Barcelona, Barcelona, Spain

Abstract

Key Points Nbs1 is a component of the MRE11 complex, which is a sensor of DNA double-strand breaks and plays a crucial role in the DNA damage response. In mice with a hypomorphic allele of Nbs1, macrophages exhibit increased senescence and abnormal proliferation and inflammatory responses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/22/2502/1390760/2502.pdf

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