Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome

Author:

Weber Daniela1,Oefner Peter J.2,Hiergeist Andreas3,Koestler Josef3,Gessner André3,Weber Markus4,Hahn Joachim1,Wolff Daniel1,Stämmler Frank5,Spang Rainer5,Herr Wolfgang1,Dettmer Katja2,Holler Ernst1

Affiliation:

1. Department of Hematology and Oncology, Internal Medicine III, University Medical Center, Regensburg, Germany;

2. Institute of Functional Genomics, University of Regensburg, Regensburg, Germany;

3. Institute of Clinical Microbiology and Hygiene and

4. Department of Orthopedic Surgery, University Medical Center, Regensburg, Germany; and

5. Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

Abstract

Key Points Urinary 3-IS levels predict outcome after ASCT and are associated with antibiotics and NOD2/CARD15 variants.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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