Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders

Author:

Balakumaran Arun1,Mishra Prasun J.2,Pawelczyk Edyta3,Yoshizawa Sayuri1ORCID,Sworder Brian J.1,Cherman Natasha1,Kuznetsov Sergei A.1,Bianco Paolo4,Giri Neelam5,Savage Sharon A.5ORCID,Merlino Glenn2,Dumitriu Bogdan6,Dunbar Cynthia E.6,Young Neal S.6,Alter Blanche P.5,Robey Pamela G.1

Affiliation:

1. Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research,

2. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, and

3. Laboratory of Diagnostic Radiology Research, Warren G. Magnuson Clinical Center, National Institutes of Health, Department of Health and Human Services, Bethesda, MD;

4. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; and

5. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and

6. Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD

Abstract

Key Points BMSCs from patients with TBDs are abnormal and unable to support hematopoiesis. Knockdown of TERC with siRNA recapitulates the TBD-BMSC phenotype.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 30 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis;Communications Biology;2023-09-29

2. Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies;International Journal of Molecular Sciences;2022-12-02

3. Network inference with Granger causality ensembles on single-cell transcriptomics;Cell Reports;2022-02

4. Challenges of Stem-cell-based Craniofacial Regeneration;Current Stem Cell Research & Therapy;2021-08-25

5. Treatment of telomeropathies;Best Practice & Research Clinical Haematology;2021-06

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3