Immune activation of human brain microvascular endothelial cells inhibits HIV replication in macrophages-Reference-Cited by-同舟云学术

Immune activation of human brain microvascular endothelial cells inhibits HIV replication in macrophages

Published:2013-04-11 Issue:15 Volume:121 Page:2934-2942
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li Jieliang¹²,Wang Yizhong²,Wang Xu²,Ye Li²,Zhou Yu²,Persidsky Yuri²,Ho Wenzhe¹²

Affiliation:

1. Animal Biosafety Level 3 Laboratory, School of Medicine, Wuhan University, Wuhan, People’s Republic of China; and

2. Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA

Abstract

Key PointsBrain ECs possess a functional TLR3/RIG-I system that is able to mount an effective IFN induction upon immune activation. Brain ECs may be a key regulatory bystander, playing a crucial role in the BBB innate immunity against HIV infection.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/15/2934/1365557/2934.pdf

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