Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling-Reference-Cited by-同舟云学术

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

Published:2013-03-28 Issue:13 Volume:121 Page:2440-2451
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Malinge Sébastien¹,Thiollier Clarisse²,Chlon Timothy M.¹,Doré Louis C.¹,Diebold Lauren¹,Bluteau Olivier³,Mabialah Vinciane²,Vainchenker William³,Dessen Philippe²,Winandy Susan⁴,Mercher Thomas²,Crispino John D.¹

Affiliation:

1. Division of Hematology/Oncology, Northwestern University, Chicago, IL;

2. U985 and

3. U1009, INSERM, Institut Gustave Roussy, Université Paris Diderot, Villejuif, France; and

4. Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA

Abstract

Key PointsIkaros inhibits megakaryocyte specification and terminal differentiation by suppressing key megakaryocyte genes. The GATA switch inhibits Ikaros expression during megakaryocyte development.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/13/2440/1365338/2440.pdf

Reference53 articles.

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2. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.;Chou;Blood,2009

3. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells.;Ling;J Exp Med,2004

4. GATA-2 reinforces megakaryocyte development in the absence of GATA-1.;Huang;Mol Cell Biol,2009

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