Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity-Reference-Cited by-同舟云学术

Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity

Published:2013-05-16 Issue:20 Volume:121 Page:4242-4249
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Singh Nirbhai¹,Tiem Michelle¹,Watkins Ryan¹,Cho Yang Kyung²,Wang Ying¹,Olsen Thomas¹,Uehara Hironori¹,Mamalis Christina¹,Luo Ling³,Oakey Zackery¹,Ambati Balamurali K.¹

Affiliation:

1. Moran Eye Center, University of Utah, Salt Lake City, UT;

2. St.Vincent Hospital, The Catholic University of Korea, Suwon, Gyeonggi Province, South Korea; and

3. The 306th hospital of PLA, Beijing, China

Abstract

Key Points Endogenous sVEGFR-3 that is expressed by the cornea binds and sequesters VEGF-C and is critical for corneal alymphaticity. sVEGFR-3 overexpression enhances murine corneal graft transplant survival 5-fold by blocking lymphangiogenesis and hemangiogenesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/20/4242/531159/4242.pdf

Reference37 articles.

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4. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele.;Carmeliet;Nature,1996

5. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.;Karkkainen;Nat Immunol,2004

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