Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells-Reference-Cited by-同舟云学术

Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells

Published:2013-06-13 Issue:24 Volume:121 Page:4875-4883
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Guo Qiuye¹²,Zhang Jinjun¹,Li Jingyi¹³,Zou Liyun¹,Zhang Jinyu¹,Xie Zunyi¹,Fu Xiaolan¹,Jiang Shan⁴,Chen Gang⁵,Jia Qingzhu⁵,Li Fei⁵,Wan Ying⁵,Wu Yuzhang¹

Affiliation:

1. Institute of Immunology, People's Liberation Army, Third Military Medical University, Chongqing, China;

2. Institute of Genetic Engineering, Southern Medical University, Guangzhou, China;

3. Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China;

4. Department of Immunology, Duke University Medical Center, Durham, NC; and

5. Biomedical Analysis Center, Third Military Medical University, Chongqing, China

Abstract

Key Points miR-146a may be involved in the pathogenesis of ALPS by targeting Fas. Sustained expression of miR-146a in B cells is the major factor leading to the enhanced homeostatic expansion of B and T cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/24/4875/1366729/4875.pdf

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