Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells-Reference-Cited by-同舟云学术

Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells

Published:2013-03-28 Issue:13 Volume:121 Page:2452-2461
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

van den Boom Vincent¹,Rozenveld-Geugien Marjan¹²,Bonardi Francesco¹,Malanga Donatella³,van Gosliga Djoke¹,Heijink Anne Margriet¹,Viglietto Giuseppe⁴,Morrone Giovanni⁵,Fusetti Fabrizia⁶,Vellenga Edo¹,Schuringa Jan Jacob¹

Affiliation:

1. Department of Experimental Hematology and

2. Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

3. Department of Experimental and Clinical Medicine, University of Catanzaro Magna Græcia, Catanzaro, Italy;

4. Biogem Scarl, Institute for Genetic Research Geatano Salvatore, Ariano Irpino, Italy;

5. Laboratory of Molecular Hematopoiesis, University of Catanzaro Magna Græcia, Catanzaro, Italy; and

6. Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands Proteomics Centre & Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands

Abstract

Key Points Knockdown of individual PRC1 members in human stem/progenitor cells revealed a lack of redundancy between various paralog family members. CBX2 was identified as an important regulator of p21/CDKN1A independent of BMI1/PCGF4.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/13/2452/1364700/2452.pdf

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