Genome-wide study of methotrexate clearance replicates SLCO1B1-Reference-Cited by-同舟云学术

Genome-wide study of methotrexate clearance replicates SLCO1B1

Published:2013-02-07 Issue:6 Volume:121 Page:898-904
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ramsey Laura B.¹,Panetta John C.¹,Smith Colton¹,Yang Wenjian¹,Fan Yiping²,Winick Naomi J.³,Martin Paul L.⁴,Cheng Cheng⁵,Devidas Meenakshi⁶,Pui Ching-Hon⁷,Evans William E.¹,Hunger Stephen P.⁸,Loh Mignon⁹,Relling Mary V.¹

Affiliation:

1. Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN;

2. Department of Computational Biology, St Jude Children's Research Hospital, Memphis, TN;

3. Department of Pediatric Neuro-Oncology, University of Texas Southwestern Medical Center, Dallas, TX;

4. Department of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC;

5. Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN;

6. Children's Oncology Group Statistics and Data Center and the University of Florida, Gainesville, FL;

7. Department of Oncology, St Jude Children's Research Hospital, Memphis, TN;

8. University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; and

9. Oncology Clinic, University of California, San Francisco, San Francisco, CA

Abstract

Key Points A genome-wide study of the association of over 5 million SNPs with methotrexate clearance in 1279 patients treated with HDMTX in multicenter COG trials 9904 and 9905. We replicated the finding that inherited variations in SLCO1B1 are the most important genetic variations influencing methotrexate clearance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/6/898/1367767/zh800613000898.pdf

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