Who is the better donor for older hematopoietic transplant recipients: an older-aged sibling or a young, matched unrelated volunteer?

Author:

Alousi Amin M.1,Le-Rademacher Jennifer2,Saliba Rima M.1,Appelbaum Frederick R.3,Artz Andrew4,Benjamin Jonathan5,Devine Steven M.6,Kan Fangyu7,Laughlin Mary J.8,Lazarus Hillard M.9,Liesveld Jane10,Perales Miguel-Angel11,Maziarz Richard T.12,Sabloff Mitchell13,Waller Edmund K.14,Eapen Mary2,Champlin Richard E.1

Affiliation:

1. Department of Stem Cell Transplant and Cellular Therapy, University of Texas, M.D. Anderson Cancer Center, Houston, TX;

2. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

3. Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA;

4. University of Chicago, Chicago, IL;

5. Stanford University School of Medicine, Stanford, CA;

6. The Ohio State University Comprehensive Cancer Center, Columbus, OH;

7. National Marrow Donor Program, Minneapolis, MN;

8. University of Virginia Health Systems, Charlottesville, VA;

9. Case Western Reserve University, Cleveland, OH;

10. University of Rochester Medical Center, Rochester, NY;

11. Memorial Sloan-Kettering Cancer Center, New York, NY;

12. Oregon Health and Science University, Portland, OR;

13. Ottawa Hospital, Ottawa, ON, Canada;

14. Winship Cancer, Emory University, Atlanta, GA

Abstract

Key Points HLA-matched siblings are better than HLA-matched unrelated donors for patients with good performance scores Survival rates are comparable after HLA-matched sibling and unrelated donor transplantations for patients with poor performance scores

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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