Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B–cell differentiation-Reference-Cited by-同舟云学术

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B–cell differentiation

Published:2013-03-07 Issue:10 Volume:121 Page:1769-1782
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ferreirós-Vidal Isabel¹²,Carroll Thomas²,Taylor Benjamin¹²,Terry Anna¹²,Liang Ziwei¹²,Bruno Ludovica¹²,Dharmalingam Gopuraja²,Khadayate Sanjay²,Cobb Bradley S.¹²,Smale Stephen T.³,Spivakov Mikhail⁴,Srivastava Prashant⁵,Petretto Enrico⁵,Fisher Amanda G.¹²,Merkenschlager Matthias¹²

Affiliation:

1. Lymphocyte Development Group, and

2. Epigenetics Section, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom;

3. Department of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, University of California, Los Angeles, CA;

4. European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; and

5. Integrative Genomics and Medicine Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom

Abstract

Key Points We identify genes that are bound and regulated by Ikaros in pre-B cells. Ikaros dosage drives the differentiation of cycling (Fr.C') to resting (Fr.D) pre-B cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/10/1769/1363313/1769.pdf

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