H3 K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations-Reference-Cited by-同舟云学术

H3 K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations

Published:2017-11-16 Issue:20 Volume:130 Page:2204-2214
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lehnertz Bernhard¹,Zhang Yu Wei¹,Boivin Isabel¹,Mayotte Nadine¹,Tomellini Elisa¹,Chagraoui Jalila¹,Lavallée Vincent-Philippe¹²,Hébert Josée¹²³⁴,Sauvageau Guy¹²³⁴

Affiliation:

1. Leucegene Project, Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada;

2. Division of Hematology and

3. Leukemia Cell Bank of Quebec, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; and

4. Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada

Abstract

Key Points First characterization of neomorphic H3K27 mutations in AML. H3 K27 mutations are associated with and collaborate with RUNX1 mutations and translocations.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/20/2204/1403401/blood774653.pdf

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5. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation;Yap;Blood,2011

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