Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma

Author:

McDonald Michelle M.12ORCID,Reagan Michaela R.34ORCID,Youlten Scott E.12ORCID,Mohanty Sindhu T.1,Seckinger Anja5,Terry Rachael L.12,Pettitt Jessica A.1,Simic Marija K.1,Cheng Tegan L.6ORCID,Morse Alyson6ORCID,Le Lawrence M. T.1,Abi-Hanna David12ORCID,Kramer Ina7,Falank Carolyne4,Fairfield Heather4,Ghobrial Irene M.3,Baldock Paul A.12,Little David G.6,Kneissel Michaela7,Vanderkerken Karin8,Bassett J. H. Duncan9,Williams Graham R.9,Oyajobi Babatunde O.10,Hose Dirk5,Phan Tri G.12ORCID,Croucher Peter I.12

Affiliation:

1. The Garvan Institute of Medical Research, Sydney, NSW, Australia;

2. St. Vincent’s School of Medicine, University of New South Wales, Sydney, NSW, Australia;

3. Dana-Farber Cancer Institute, Boston, MA;

4. Maine Medical Center Research Institute, Scarborough, ME;

5. UniversitätsKlinikum Heidelberg, Medizinische Klinik V, Labors für Myelomforschung, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany;

6. Centre for Children’s Bone and Musculoskeletal Health, The Children’s Hospital at Westmead, Sydney, NSW, Australia;

7. Novartis Institutes for Biomedical Research, Basel, Switzerland;

8. Faculty of Medicine, Department of Hematology and Immunology, Frei University, Brussels, Belgium;

9. Department of Medicine, Molecular Endocrinology Laboratory, Imperial College, London, United Kingdom; and

10. University of Texas Health Science Center, San Antonio, TX

Abstract

Key Points Anti-sclerostin treatment increases bone mass and fracture resistance in MM Anti-sclerostin in combination with zoledronic acid is superior to zoledronic acid alone in increasing fracture resistance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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