Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children’s Oncology Group report-Reference-Cited by-同舟云学术

Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children’s Oncology Group report

Published:2017-06-08 Issue:23 Volume:129 Page:3051-3058
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vujkovic Marijana¹^ORCID,Attiyeh Edward F.¹,Ries Rhonda E.²^ORCID,Goodman Elizabeth K.¹,Ding Yang¹,Kavcic Marko³,Alonzo Todd A.⁴^ORCID,Wang Yi-Cheng⁵,Gerbing Robert B.⁵,Sung Lillian⁶^ORCID,Hirsch Betsy⁷^ORCID,Raimondi Susana¹⁸,Gamis Alan S.⁹^ORCID,Meshinchi Soheil²^ORCID,Aplenc Richard¹^ORCID

Affiliation:

1. Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA;

2. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Unit of Oncology and Hematology, University Medical Centre, Ljubljana, Slovenia;

4. Keck School of Medicine, University of Southern California, Los Angeles, CA;

5. Children’s Oncology Group, Monrovia, CA;

6. Hospital for Sick Kids, Toronto, ON, Canada;

7. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN;

8. St Jude Children’s Research Hospital, Memphis, TN; and

9. Division of Hematology/Oncology/Bone Marrow Transplantation, Children’s Mercy Hospitals & Clinics, Kansas City, MO

Abstract

Key Points Pediatric patients with de novo AML on average acquire 1.14 somatic CNAs in a study sample of 446 patients. The presence of CNAs is significantly associated with survival in standard-risk patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/23/3051/1401019/blood772384.pdf

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