Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis-Reference-Cited by-同舟云学术

Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis

Published:2017-12-21 Issue:25 Volume:130 Page:2786-2798
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

von Wnuck Lipinski Karin¹,Weske Sarah¹,Keul Petra¹,Peters Susann¹,Baba Hideo A.²,Heusch Gerd¹,Gräler Markus H.³⁴,Levkau Bodo¹

Affiliation:

1. Institute for Pathophysiology, West German Heart and Vascular Center and

2. Institute for Pathology, University Hospital Essen, Essen, Germany;

3. Department of Anesthesiology and Intensive Care Medicine, Center for Sepsis Control and Care and

4. Center for Molecular Biomedicine, University Hospital Jena, Jena, Germany

Abstract

Key Points HNF1A deficiency in mice leads to non–cell-autonomous anemia caused by altered red blood cell (RBC) sphingolipids leading to hemolysis. Sphingosine loading of WT RBCs phenocopies osmotic fragility and high calcium of HNF1A−/− RBCs due to suppressed plasma-membrane Ca2+-ATPase.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/25/2786/1404260/blood774356.pdf

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