Outcomes of hematopoietic cell transplantation using donors or recipients with inherited chromosomally integrated HHV-6

Author:

Hill Joshua A.12,Magaret Amalia S.234,Hall-Sedlak Ruth3,Mikhaylova Anna4,Huang Meei-Li3,Sandmaier Brenda M.15,Hansen John A.15,Jerome Keith R.23,Zerr Danielle M.16,Boeckh Michael12

Affiliation:

1. Department of Medicine, University of Washington, Seattle, WA;

2. Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Department of Laboratory Medicine and

4. Department of Biostatistics, University of Washington, Seattle, WA;

5. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and

6. Department of Pediatrics, University of Washington, Seattle, WA

Abstract

Key Points Inherited ciHHV-6 was detected in 1.4% of HCT recipients and 0.9% of their donors. Acute GVHD grades 2-4 and cytomegalovirus viremia were more frequent when recipients or donors had inherited ciHHV-6.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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