NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival-Reference-Cited by-同舟云学术

NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

Published:2017-08-24 Issue:8 Volume:130 Page:1014-1025
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Prince Lynne R.¹,Prosseda Svenja D.¹,Higgins Kathryn¹,Carlring Jennifer¹,Prestwich Elizabeth C.¹,Ogryzko Nikolay V.²,Rahman Atiqur¹,Basran Alexander¹,Falciani Francesco³,Taylor Philip⁴,Renshaw Stephen A.¹²,Whyte Moira K. B.⁵,Sabroe Ian¹

Affiliation:

1. Department of Infection, Immunity and Cardiovascular Disease and

2. Bateson Centre, University of Sheffield, Sheffield, United Kingdom;

3. Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom;

4. Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom; and

5. MRC Centre for Inflammation Research, Queen's Medical Institute, University of Edinburgh, Edinburgh, United Kingdom

Abstract

Key Points We demonstrate an important role for NR4A receptors in regulating neutrophil lifespan and homeostasis in vitro and in vivo. These findings may define targets for therapies for diseases driven by defects in neutrophil number and/or survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/8/1014/1404808/blood770164.pdf

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